ISAP ... founded in 1991


7th ISAP International Symposium
Advances in the Pharmacology of Antiinfective  Therapy
co-sponsored with Astra Research Centre, India

January 20-22 (Thursday - Saturday), 2000, National Science Seminar complex, Indian Institute of Science, Bangalore, Karnataka, India

Goals and Objectives | Programme and slides of the meeting | Host Institutions | Credits

The slides presented by the some of the speakers at this workshop are available on this site as "Web slide shows" (view per slide) and as "PDF files" (download the whole presentation).  To access either of tehm, click on the title of the lectures.  These slides, which reflect the views of their authors and should not be taken as being endorsed by ISAP, are for information purposes only.  They cannot be reproduced or used for any form of  presentations without the autorization of their author and of ISAP. Please, contact the ISAP Webmaster for further information.


Flowers in Bangalore...

  • Trends & Problems in Therapy with Antibacterial Drugs (O. Cars, Uppsala, Sweden)
  • Pharmacokinetic concepts (O. Cars, Uppsala, Sweden)
  • Pharmacodynamic concepts (W.A. Craig, Madison, WI)
  • Intracellular pharmacodynamics (P.M. Tulkens, Brussels, Belgium)
  • In vitro pharmacodynamic models in the development of antibacterials (E. Löwdin, Uppsala, Sweden)
  • Animal models in early evaluation of  antibacterial agents (N. Frimødt-Møller, Copenhagen, Denmark)
  • Use of animal models to define pharmacokinetic  and pharmacodynamic interactions and optimal doses of antibacterial drugs (W.A. Craig, Madison, WI)
  • Slide Presentations on In vivo models for the determination of antibacterial efficacy: advantages and limitations (N. Frimødt-Møller, Copenhagen, Denmark & W.A. Craig, Madison, WI)
  • Problems in the treatment of tuberculosis (J. Nachega, Baltimore, Md)
  • Prediction of clinical efficacy of antitubercular regimens from in vitro studies (C. Paramasivan, Chennai, India)
  • Animal efficacy studies of antitubercular agents (V. Balasubramanian, AstraZeneca R&D Indian Site, Bangalore, India)
  • Evaluation of Clinical Efficacy and Optimal dosing from Clinical Trials (G. Drusano, Albany, NY [talk delivered by W.A. Craig, due to the illness of the speaker])
  • Design of Clinical Studies of Antibacterial Agents for Efficacy and Toxicity (R. Norrby, Lund, Sweden)
  • Can we obtain useful susceptibility reports ? (Naniwadekar, ...)
  • Prediction and prevention of emergence of resistance of clinically used antibacterials (F. Baquero, Madrid, Spain)
  • Regulatory efficacy requirements of new antibacterial drugs (talk delivered by W.A. Craig, Madison, WI, on behalf of the U.S. Food and Drug Administration)
  • Industrial Aspects of the development of Antibiotics (J. Edwards, Alderley Park, UK)
  • Closing remarks (S. Rosell, Umeå Sweden & P.M. Tulkens, Brussels, Belgium)


  • Goals and objectives

        One of the main goals of ISAP is to disseminate the concepts as well as the practical knowledge of Pharmacokinetics and Pharmacodynamics (PK/PD) of antiinfectives within the scientific and clinical community.  In this context, ISAP is regularly sponsoring scientific meetings  where ISAP members and/or experts in PK/PD of antiinfectives address invited audiences to review the recent progresses, discuss their potential applications and answer specific questions in their domains of expertise.

        The present meeting was typically meant at bringing to an international audience, with emphasis on Asia, the knowledge developed by ISAP over the last years through the scientific activities of its members on the one hand and through contacts with regulatory agencies on the other hand, so that new drugs will be used in the most appropriate fashion with respect to the three main criteria of efficacy, lack of toxicity and prevention of emergence of resistance.  The symposium dealt with pharmacodynamic and parmacokinetic properties of antibacterial agents as determined in in vitro and in vivo models and their use for prediction and evaluation of the performance of the agents and the use of this information for development, clinical use and registration of
    the latter. Special attention was also be given to tuberculosis, an old but still highly threatening disease in emerging countries.

         The meeting was open all scientists in academia and industry. The focus of the programme was on active interaction with the audience in order to provide both researchers and clinicians an as effective as possible guidance for successful future work and achievements in antiinfective therapy. 


    Host  Institutions

    Astra Research Centre India (ARCI).

    ARCI is situated in Bangalore, state of Karnataka, India and was founded in 1986. It is a non-profit organization, a Society under the laws of Karnataka, with the objective to support scientific developments in India, particularly with regard to infectious diseases. The Society, comprising Indian and Swedish scientists as members, is headed by a Director, Dr. S. Anand Kumar and has a Governing Board with three members appointed by the Government of India, Department of Science and Technology and three members appointed by Astra AB, Sweden (now AstraZeneca, PLC, UK). The activities of ARCI are financed mainly by returns on a corpus fund owned by the Society and to some extent by a contribution from AstraZeneca.  The Society has decided to change its name into AstraZeneca Research Foundation India but the new name has not yet become official.

    Indian Institute of Science (IISc)

    Started in 1909 through the pioneering vision of J.N. Tata, IIScin Bangalore has  grown into a premier institution of research and advanced instruction (2000 researchers) in frontier areas of science and technology, with a very high international standing.

    The National Center for Biological Sciences (NCBS)

    New centre of the Tata Institute of Fundamental Research, NCBS conducts basic research in the frontier areas of     Structural and Cell Biology, Biology of Disease, Neurogenetics, and Molecular and Systems Neuroscience.


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    Credits:
    last significant update: February 2d, 2000