Animal Models in Early Evaluation of Antibacterial Agents

03/02/00

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Table of Contents

Animal Models in Early Evaluation of Antibacterial Agents

Experimental animal experiments: History

Experimental animal models: Definition of antibiotic effect in special situations

Why animal models ?

Experimental animal models: Manipulation/modulation

Animal experimentation in antibiotic research: Ethical issues

Screening of substances for antimicrobial activity in vivo: Considerations prior to animal experimentation

Experimental animal model: Choice of animal

Factors influencing antimicrobial activity in in vivo tests

Experimental animal model: Choice of bacterium

Methods of immunesuppression for enhancement of virulence of bacteria for inoculation

Mouse peritonitis model: Vancomycin and teichoplanin against ten PRP with Pen MIC´s from 0.016 to 8 mg/l

Effect of schedule of administration on therapeutic efficacy of penicillin on S. pyogenes infection in mice 

Mouse protection test: Correlation between MIC and ED50 for pneumococci with varying penicillin susceptibility

Beta-lactam antibiotics and the mouse-peritonitis model: Correlation MIC vs. effect for penicillins and cephalosporins

Experimental animal model for antibiotic effect: Importance of growth phase in vivo

Experimental animal model for antibiotic effect: Importance of growth phase in vivo

Comparison of cephalosporins against pneumococci in the mouse protection test 

Mouse protection test: Synergy between penicillin and gentamicin against pneumococci

Screening of antibacterial substances in experimental animals: Conclusion

 Author: Niels Frimodt-Møller 

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Home Page: http://www.isap.org/2000/Bangalore/intro.htm