TB and HIV/AIDS
TB is the leading killer of HIV/AIDS patients
Worldwide, 35 million people are HIV+ (~40-50% TB+)
22% of all TB deaths occur in HIV-infected people
TB is the leading AIDS-related opportunistic infection
High rate of reactivation (10%/year) and primary TB
Risk of TB correlates with positive PPD & low CD4
Selwyn PA et al. JAMA, 1992; 268:504-9
Antonucci G. et al., JAMA, 1995; 274:143-8
Havlir D. and Barnes P., NEJM, 1999;340, 367