Pharmacodynamics of Antimicrobials in Animal Models 
William A. Craig, M.D. University of Wisconsin-Madison

12/06/2000

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Table of Contents

Pharmacodynamics of Antimicrobials in Animal Models William A. Craig, M.D. University of Wisconsin-Madison 

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Determination of “Static Dose” in Murine Thigh and Lung Infections

Relationship Between 6-Hour Dose and Number of Klebsiella pneumoniae in Thighs of Neutropenic Mice

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Pharmacokinetic/Pharmacodynamic Parameters

PK/PD Parameters: ?-Lactams

Relationship Between MIC and T>MIC for Amoxicillin & Sanfetrinen with S. penumoniae

Relationship Between T>MIC and Efficacy for Amoxicillin against Streptococcus pneumoniae in Rat Pneumonia and Murine Thigh-Infection Models 

Relationship Between Time Above MIC and Efficacy in Animal Infection Models for S. pneumoniae

PK/PD Paramters with Fluoroquinolones

24-Hr AUC/MIC for Static Doses of Gatifloxacin, Sitafloxacin and Gemifloxacin Against 6 Strains of Streptococcus pneumoniae

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Relationship Between 24 Hr AUC/MIC and Mortality for Fluoroquinolones against Streptococcus pneumoniae in Immunocompetent Animals

Magnitude of PK/PD Parameter Required for Effective Dose-50 Against Candida albicans in Kidneys of Neutropenic Mice

Animal Models for Susceptibility Breakpoint Determinations

Growth of 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice

Effect of Amoxicillin (7 mg/kg) on 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice

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Author: W.A. Craig (Medical Media Production Service) 

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