PPT Slide

Pharmacodynamics of Fluoroquinolones

• Magnitude of 24-Hr AUC/MIC in serum required for 90-100% survival in animal infection models varies from about 25 in immunocompentent animals for Streptococcus pneumoniae to about 100 in immunocompromised animals for gram-negative bacilli

• 24-Hr AUC/MIC values of 25 and 100 are equivalent to averaging one and four times the MIC over a 24-hr period

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