PPT Slide
Comparison of Emax-model vs. MIC
Emax-model is two-dimensional (Emax, EC50) whereas MIC is mono-dimensional.
Emax-model allows for gradual changes in pharmacodynamic activity whereas MIC is a threshold value.
Emax-model can be integrated in PK-PD models to characterize the complete effect-time-relationship whereas MIC can only be used in integrated models (AUIC, t>MIC).
Emax-model is more complex than MIC. However, today’s computer software can handle this with ease.
Emax-model allows for more differentiated dose recommendation based on microbiological data than MIC.