Table of Contents
Synergism : what does it mean?
RATIONALE FOR ANTIMICROBIAL COMBINATIONS
Classical definition of Synergism
SYNERGISM
SYNERGISM : IN VITRO METHODS
SYNERGISM DEFINITIONS TIME KILL CURVES
SYNERGISM DEFINITIONS TIME KILL CURVES
PPT Slide
PPT Slide
Synergism by E-test White et al, 1996
Functions of drug concentration
Synergy, Checkerboard
Simple Isobole Constraints
URSA Universal Response Surface Approach
URSA
Bliss Independence Effects Equation
Zero Surface Substraction Bliss
SYNERGISM DEFINITIONS checkerboard
SYNERGISM EXPRESSIONS checkerboard
PREDICTION OF EFFICACY combination regimens
PPT Slide
CONCLUSIONS |
Author: J. Mouton
Email: webmaster@isap.org
Home Page: http://www.isap.org/2000/Workshop-Stockholm/intro.htm
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