Pharmacodynamic parameters
Minimal inhibitory concentration; MIC
Differences between MIC determinations in vitro and in vivo
MIC methods
Correlation between MIC and in vivo efficacy
Time-killing curves
Concentration dependent vs. non-dependent killing
Tolerance
Paradoxical effect "Eagle effect"
Control related effective regrowth time; CERT
Conclusions
The postantibiotic and sub-MIC effects in vitro and in vivo
Postantibiotic effect; PAE in vitro
Postantibiotic effect in vitro
PAE in vitro Methods
Postantibiotic effect in vivo
PAE in vivo
PAE in vivo Animal models
Mechanisms of PAE
Postantibiotic sub-MIC effect; PA SME
Post-MIC effect; PME
Mechanism of PA SME?
Postantibiotic leucocyte enhancement; PALE
Sub-MIC effects; SME
Sub-MIC effects
Mechanism of sub-MIC effects
Email: webmaster@isap.org
Home Page: http://www.isap.org/2000/Workshop-Stockholm/intro.htm