CONCENTRATION EFFECT RELATIONSHIPS FOR INTRACELLULAR MICRO-ORGANISMS :

13/06/00

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CONCENTRATION EFFECT RELATIONSHIPS FOR INTRACELLULAR MICRO-ORGANISMS :

These they are…

How to predict efficacy in the intracellular milieu ?

Can MIC be predictive ?

How to predict efficacy in the intracellular milieu ?

How to predict efficacy in the intracellular milieu ?

Pharmacokinetics : intracellular MIC ?

Pharmacokinetics : intracellular MIC ?

Why are acidic drugs excluded ?

Why do basic drugs accumulate ?

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Pharmacokinetic modulation of intracellular activity: drug trapping 

Pharmacokinetic modulation of intracellular activity: drug trapping 

Pharmacokinetic modulation of intracellular activity: active efflux 

Pharmacokinetic modulation of intracellular activity: active efflux 

Pharmacokinetic modulation of intracellular activity: active efflux 

Pharmacokinetic modulation of intracellular activity: active efflux 

Pharmacodynamics : intracellular MIC ?

Pharmacodynamics : intracellular MIC ?

Pharmacodynamics : intracellular MIC ?

Pharmacodynamic modulation of intracellular activity: expression of activity 

Pharmacodynamic modulation of intracellular activity: cooperation - host defenses 

Concentration - effect relationships for intracellular micro-organisms 

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 Author: F. Van Bambeke & P.M. Tulkens

Email: webmaster@isap.org

Home Page: http://www.isap.org/2000/Workshop-Stockholm/intro.htm