8th ISAP Symposium
Developments in Pharmacokinetics and Pharmacodynamics (PK/PD):
optimizing efficacy and prevention of resistance
Nijmegen, The Netherlands, July 4th-6th, 2001

A Critical Review of PK/PD in Animal Models

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Animal Versus In-Vitro Models

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Ceftriaxone Total plasma and free tissue levels in rats

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Effect of Increasing Concentrations on Killing of Pneumococci in Thighs of Neutropenic Mice

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In Vivo PAE for Azithromycin with Streptococcus pneumoniae ATCC 10813 in Thighs of Neutropenic Mice

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PK/PD In-vivo Model Variables

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Correlation of PK/PD Parameters with Efficacy of Levofloxacin against Streptococcus pneumoniae in Thighs of Neutropenic Mice

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Relationships Between PK/PD Parameters and Efficacy of ABT-773 with Streptococcus pneumoniae ATCC 10813

Impact of DosingFrequency on Static Dose for Macrolides, Azalides and Ketolides with Streptococcus pneumoniae ATCC 10813

Impact of Dose Fractionation on the Efficacy of Glycopeptides in a Murine Peritonitis Model

Pharmacodynamics of Lomefloxacin in a Neutropenic Rat Model of Pseudomonas

Half-lives in Mice and Humans

Once-Daily Dosing of Aminoglycosides in Animals

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Pharmacokinetic/Pharmacodynamic Parameter Correlating with Efficacy of Amikacin Against Gram-Negative Bacilli in Thighs and Lungs of Neutropenic Mice with Normal and Impaired Renal Function

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Survival/Mortality Studies

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Magnitude of Static Dose (mg/kg) Required in Thigh and Lung Models in Neutropenic Mice Infected with Klebsiella pneumoniae

24-Hr AUC/MIC for Static Doses of Gatifloxacin, Sitafloxacin and Gemifloxacin Against 6 Strains of Streptococcus pneumoniae

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Relationship Between 24 Hr AUC/MIC and Mortality for Fluoroquinolones against Gram-Negative Bacilli

Relationship Between 24 Hr AUC/MIC and Mortality for Fluoroquinolones against Streptococcus pneumoniae

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Intracellular Concentrations of Fluoroquinolones vs Intracellular Pathogens

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Conclusions

Author: David Andes

Email: webmaster@isap.org

Home Page: http://www.isap.org/slides.htm

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A Critical Review of PK/PD in Animal Models

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