8th ISAP Symposium
Developments in Pharmacokinetics and Pharmacodynamics (PK/PD):
optimizing efficacy and prevention of resistance
Nijmegen, The Netherlands, July 4th-6th, 2001

Rational dosing: the use of plasma concentrations versus tissue concentrations

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PPT Slide

Significance of free tissue levels

Example Development of an Oral Sustained Release Formulation for Cefaclor

PPT Slide

Microdialysis in Muscle

Lung Microdialysis

Cefaclor in Rats Total plasma and free tissue levels

Conclusions - Rats

Human study

Probe insertion

Plasma and free tissue levels

Conclusions Cefaclor-Study

Author: Hartmut Derendorf

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Rational dosing: the use of plasma concentrations versus tissue concentrations

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