8th ISAP Symposium
Developments in Pharmacokinetics and Pharmacodynamics (PK/PD):
optimizing efficacy and prevention of resistance
Nijmegen, The Netherlands, July 4th-6th, 2001

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

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The Team N. L. Jumbe, A. Louie, W. Liu,V. Tam, T. Fazili, R. Leary, C. Lowry, M.H. Miller and G. L. Drusano

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

S. pneumoniae outcome studies

P. aeruginosa outcome studies

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

PPT Slide

Mean Parameter Estimates of the Model.

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

PPT Slide

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Study Design: Mouse Thigh Infection Model- Ciprofloxacin Studies [50mg/kg BID ~ AUC/MIC 100:1]

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

PPT Slide

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Prevention of Emergence of Resistance: A Pharmacodynamic Solution CONCLUSIONS

Prevention of Emergence of Resistance: A Pharmacodynamic Solution Target Attainment

Prevention of Emergence of Resistance: A Pharmacodynamic Solution

Author: George L. Drusano

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Prevention of Emergence of Resistance: A Pharmacodynamic Solution

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