Use of pk/pd in breakpoint setting

July 5th, 2001

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Table of Contents

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A conflict of breakpoints? 

Use of Pharmacodynamics in setting breakpoints 

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Pharmacodynamic Indices predictive for efficacy 

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AUIC =125 : a magical number?? 

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T>MIC: how long?? breakpoints 

Same all beta-lactams? Same all m.o.?

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MPC 

MIC/MPC 

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Breakpoints : betalactams Which T>MIC do we need?

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Ceftazidime concentrations ICU patients

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T>MIC: how long?? breakpoints 

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Conclusions 

Author: Johan W. Mouton 

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