Can PK/PD be used in everyday clinical practice?

Table of Contents

PK/PD results and evolution

Several objectives

PK/PD evolution

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Optimizing antimicrobial therapy

PHARMACODYNAMICS

Improving the probability of positive outcomes

PK/PD parameters determining efficacy

Peak level of tobramycin 3mg/kg in ten patients in ICU

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Ideal approach to adjust the dose

First problem PK approach to adjust the dose is poor applicable for routinely use (at moment)

second problem PK/PD breakpoints

Program to customize the therapy in our hospital

PK/PD values adopted

Sampling time

Concentrations of ceftazidime and cefotaxime in serum

Peak levels of amikacin

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preliminary results

diagnosis

Organisms isolated

Aminoglicosides Dose adjusted according to creatinine clearance

Ceftazidime-Cefotaxime-Levofloxacin Dose adjusted according to creatinine clearance

Ciprofloxacin Dose adjusted according to creatinine clearance

outcome

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Conclusions I

Conclusions II

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Conclusions IV homework

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