8th ISAP Symposium
Developments in Pharmacokinetics and Pharmacodynamics (PK/PD):
optimizing efficacy and prevention of resistance
Nijmegen, The Netherlands, July 4th-6th, 2001 The slides presented by the some of the speakers at this workshop are available on this site as "Web slide shows" and as ".PDF files".  To view and/or to download them, click on the title of the lectures.  These slides, which reflect the views of their authors and should not be taken as being endorsed by ISAP, are for information purposes only.  They cannot be reproduced or used for any form of  presentations without the autorization of their author and of ISAP. Please, contact the ISAP Webmaster for further information.

 
 

The old city of Nijmegen ...


The Valkhof Castle in Nijmegen
  • Opening lecture: Ten years after: where is ISAP ?

    • William A. Craig (Madison, WI)
  • A critical review of PK/PD in animal models

    • David Andes (Madison, WI)
  • A critical review of PK/PD in in vitro  models

    • Alasdair MacGowan (Bristol, UK)
  • A critical review of PK/PD in preventing toxicity

    • Paul M. Tulkens (Brussels, Belgium)
  • How predictive is PK/PD ?

    • Niels Frimødt-Møller (Copenhagen, Denmark)
  • The use of PK/PD in breakpoints settings

    • Johan W. Mouton (Nijmegen, The Netherlands)
  • Rational dosing: animals versus humans

    • Peter Lees (Hatfield, UK)
  • Rational dosing: the use of plasma concentrations versus tissue concentrations

    • Hartmut Derendorf (Gainesville, FL) 
  • The future of Phase 1, 2, and 3 trials

    • Philippe Colangelo (Rockville, MD)
  • The use of PK/PD in drug development: 5 years from now

    • Michael N. Dudley (Mountain View, CA)
  • Prevention of resistance using PK/PD

    • George L. Drusano (Albany, NY) 
  • Can PK/PD be used in everyday clinical practice?

    • Francesco Scaglione (Milan, Milan, Italy)

    Goals and Format

    At the occasion of its 10th anniversary, the International Society of Antiinfective Pharmacology (ISAP) has invited all persons interested for a two-days symposium in Nijmegen, The Netherlands, for what promised to be a challenging programme.  During the first part of the meeting, several speakers have set the tone by reviewing what had been acquired over the last 10 years on pharmacokinetics and pharmacodynamics of antiinfective drugs .  They also discussed the implications of these findings for the curbing of resistance, the fine-tuning of antimicrobial therapy, and the development process of new antiinfectives.  The second part of the programme was intended to be provocative, to evoke many discussions, and to start a debate on future research orientations.  In this sense, the meeting has continued the tradition of the "ISAP Symposia" started in 199, and will has set up the scene for continuing progresses in pharmacokinetics and pharmacodynamics of antiinfective agents.

    Participants awere expected to be knowledgeable in basic pharmacokinetics and in antiinfective therapy, but speakers endeavoured to provide appropriate explanation and education on all the new concepts which have been be presented.  Ample time was be given for in-depth discussion after each lecture.

    Each participant has received a certificate for participation.

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    Credits