Pharmacokinetics of Antimicrobials in Animals: Lessons Learned

ISAP 4th Educational Workshop, Istanbul, Turkey, April 1st, 2001

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Table of Contents

Pharmacokinetics of Antimicrobials in Animals: Lessons Learned William A. Craig, M.D. University of Wisconsin-Madison 

Value of Animal Models

PPT Slide

Half-Lives in Mice and Humans

Pharmacokinetics of Ciprofloxacin in Animals

Ways to Reduce Clearance and Prolong Half-life

Serum Protein Binding of Antimicrobials in Animals

Serum Protein Binding of Antimicrobials in Animals

PPT Slide

PPT Slide

PPT Slide

PPT Slide

PPT Slide

PPT Slide

Three-Compartment Model

Serum Levels of Penicillin G in Mice

Pharmacokinetics of Penicillin G In Human Volunteers

Impact of Gamma-Phase on Duration of In-Vivo Postantibiotic Effect in Mice

Other Factors to Consider with Pharmacokinetics in Animal Models

Conclusions

Author: William A. Craig

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