Pharmacodynamics – why?
Ecological unwanted effects
Antibiotic effects
Antibiotic effects in the following
Definitions
Dose-response-relationships
Pharmacodynamics
Linear model
Log-linear model
EMAX-model
Sigmoid model (variable slope)
Predictive parameters
Effect on microorganisms
How to identify the predictive parameter(s) in vivo
PPT Slide
Parameters with dosing
Azithromycin, one pneumococcus, different regimens
Teicoplanin and vancomycin, one pneumococcus, many dosing regimens
Teicoplanin and vancomycin II
Penicillin-G, ten pneumococci, many dosing regimens
Future focus on PK/PD
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