Ecological unwanted effects

• Resistance developments

JL Martinez et al. Antimicrob Agent Chemother 2000;44:1771-1777.

• Seldom in the infective microorganisms

DN Fish et al. Pharmacotherapy 1995;15:279-291.

JK Thomas et al. Antimicrobial Agent Chemother 1998;42:521-527.

• Often in the normal microflora

N Høiby. J Antimicrob Chemother 2000;46:Suppl.1:59-62.

R Dagan et al. J Antimicrob Chemother 2001;47:129-140.

----many studies----

• Selection af unwanted microorganisms

  • Always?

F Baquero et al. J Chemother 1999;suppl.1:35-43.

----we all know about Candida, Clostridium difficile, Enterococci, etc. ----

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