How to identify the predictive parameter(s) in vivo

• Explore the correlation between effect and various PK/PD parameters:

  • One drug, one microorganism, many dosing regimens
  • One drug, many microorganisms, one dosing regimen
  • More drugs from the same class of antibiotics, one or more organisms, one or more dosing regimens

• Study the PK/PD parameters at a certain effect

  • The PK/PD parameters at ED50 for many organisms and one drug

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