Penicillin-G, ten pneumococci, many dosing regimens

Determination of ED50s and the correlation to MICs

For each ED50 the PK/PD parameters were measured/calculated:

T>MIC: 42 (24-60) min

CMAX/MIC: 38 (9-96)

AUC/MIC: 27 (7.3-72) h

JD Knudsen et al. AAC 1995;39:1253-1258.

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