PPT Slide

Intracellular transport of antibiotics -

mechanisms/significance

Accumulation

• Mechanisms involved:

diffusion, facilitated diffusion, receptor mediated-process

• But don’t forget… intracellular trapping, efflux process

Beta-Lactams <= 1x

Aminoglycosides < 1x to 2x

Ansamycins 2x to 3x

Tetracyclines 2x to 4x

Fluoroquinolones 10x to 20x

Macrolides 4x to 100x

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