PPT Slide

0.0

0.5

1.0

Intracellular activity (log(CFU 0h/24h))

Accumulation factor (Cc/Ce)

CT

AMPI

PIVA

T = 24h

(Fan et al, 1997)

Modulation of cellular pharmacokinetics/ pharmacodynamics

1. Change the physico-chemical properties of the drug

Macrophages J774

Staphylococcus

aureus

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