PPT Slide
Modulation of cellular pharmacokinetics/ pharmacodynamics
4. Cooperation with cell bactericidal mechanisms Activation of an entry transport?
Walters et al, Antimicrob. Agents Chemother. 1999 43: 2710-2715
Pharmacokinetics - In human neutrophils
Quiescent cells: Km (µg/ml): 167 ± 12
Vmax: (ng/min/106cells: 25.2 ± 2.64
Activated cells: Km (µg/ml): 9.76 ± 0.82
Vmax: (ng/min:106cells:59.3 ± 6.39
Neutrophil activation with PMA enhanced the uptake of ciprofloxacin via a system possessing amino acid transport activity