Pharmacodynamics and pharmacokinetics as a predictor to antibiotic efficacy

Presented at the Symposium “Every Day Counts in the Management of  Respiratory Tract Infections” 
held during the 11th European Congress of  Clinical Microbiology and Infectious Diseases 
(ECCMID, Istanbul, Turkey), on April 2d, 2001, and kindly made available to ISAP by the author

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Table of Contents

Pharmacodynamics and pharmacokinetics as a predictor to antibiotic efficacy

Getting it Right

Aims

PPT Slide

Pharmacokinetic factors

Pharmacodynamic factors

PPT Slide

pK/pD models

PPT Slide

Pharmacodynamic patterns (1)

Pharmacodynamic patterns (2)

The Usual and Unusual Way of Comparing Two drugs for Clinical Efficacy

In vitro PD Models

Example of Descriptive Model-1

Example of Descriptive Model-2

Ratio AUC : MIC for S. pneumoniae based on total drug levels

Analytical Models

Human data with fluoroquinolones 

Conclusions so far…

Pharmacokinetics

Potency

pK/pD parameters

but beware…

Monte Carlo simulations

PPT Slide

Results of Monte Carlo simulations used to compare respiratory fluoroquinolones against S. pneumoniae

Conclusions

Conclusions

Author: Chris Thomson 

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Home Page: http://www.isap.org/slides.htm

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