Pk/pd properties in bacterial meningitis

Table of Contents

Essential to know about pk/pd for the treatment of bacterial meningitis

Extremely great variability in reports of antibiotics penetration into CSF

How to study pk/pd ?

Rabbit model for the study of pk/pd in bacterial meningitis

The CNS compartment

1. CSF penetration of antibiotics

2. CSF penetration of antibiotics

3. CSF penetration of antibiotics

4. CSF penetration of antibiotics

CSF penetration of fluoroquinolones during experimental meningitis (AUCCSF/AUCblood or CCSF/Cserum at steady state)

CSF penetration of antibiotics during experimental meningitis (AUCCSF/AUCblood or CCSF/Cserum at steady state)

Do “normal” pharmacodynamic parameters exist in bacterial meningitis ?

Poor bacterial growth rate and bacterial killing in CSF

Need for CSF bactericidal activity 

Concentration dependent killing in CSF - Cmax -

Concentration dependent killing in CSF - AUC/MBC, T>MBC -

Concentration independent killing in CSF - Cmax -

Concentration independent killing in CSF – T>MBC -

Summary of pk/pd in bacterial meningitis

1. Antibiotic combination therapy

2. Antibiotic combination therapy

3. Antibiotic combination therapy 

1. Immunomodulations by antibiotics

2. Immunomodulations by antibiotics

3. Immunomodulations by antibiotics

Future perspectives

Acknowledgement

Email: webmaster@isap.org

Home Page: http://www.isap.org/slides.htm

Other information:
These slides are for information only. Do not make public use of them without the autorization of their author and of ISAP. Send your requests to <webmaster@isap.org> 

Download presentation as PDF file