Do “normal” pharmacodynamic parameters exist in bacterial meningitis ?

• Concentration dependent killing

  • Aminoglycosides, quinolones
  • Cmax/MIC, AUC/MIC,
  • Long persistent effects (PAE, sub-MIC effect)

• No - or little concentration dependent killing

  • ?-lactams, glycopeptides, macrolides
  • T>MIC
  • Short persistent effects

Smaller fluctuation of antibiotic concentrations in CSF than in other infection sites.

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