Summary of pk/pd in bacterial meningitis

• Concentration dependent killing

  • AUC/MBC is the most important pk/pd parameter for aminoglycosides and quinolones
  • Short persistent effects for quinolones, but not for aminoglycosides

• Concentration independent killing

  • Concentration dependent killing at 10-30 ? MBC for ?-lactams and glycopeptides
  • T>MBC is most important pk/pd parameter
  • Short persistent effects

Higher loading dose and less frequent dosing

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