3. Antibiotic combination therapy

• Synergistic effect:

  • ampicillin + gentamicin, mecillinam + ampicillin, ceftriaxone + trovafloxacin, ceftriaxone + vancomycin, vancomycin + trovafloxacin

• Antagonistic effect

  • Penicillin + chloramphenicol, methicillin + fusidic acid

• No synergistic/antagonistic effect

  • cefepine + vancomycin, meropenem + vancomycin, rifampicin + vancomycin, rifampicin + ceftriaxone, rifampicin + ofloxacin, clindamycin + vancomycin, clindamycin + ceftriaxone, clindamycin + ofloxacin, trovafloxacin + TMP-SMX

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