The general concept of pharmacokinetics and pharmacodynamics H. Derendorf  (Department of Pharmaceutics, University of Florida, Gainesville, Fla.) Antimicrobial pharmacokinetics:  lessons learned from animal models W.A. Craig (Division of Infectious Diseases, University of Wisconsin, Madison, WI) Protein binding and tissue concentrations – do they matter ?  O. Cars (Departement of Infectious Diseases, University Hospital, Uppsala, Sweden)  PK/PD indices : definitions, how to determine and interpretation J. W. Mouton (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands) Animal models of infection W.A. Craig (Division of Infectious Diseases, University of Wisconsin, Madison, WI) Sub-MIC effects I. Odenholt (Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden) Clinical Implications of PK/PD modelling J.W. Mouton (Medical Microbiology Laboratory, Canisius Whilhelmina Hospital, Nijmegen,The Netherlands)

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs.  While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999, there is presently a lack of training into these disciplines.  Accordingly, ISAP has endeavoured to launch educational activities in this context.  The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown.  This 5th workshop of ISAP will continue the tradition of educational workshops initiated in Berlin, Germany, in 1999.  It will be mostly geared to people wishing to gain an Introduction to this exciting field.

• Objectives: Participants were to gain insight in the basics of pharmacokinetic and pharmacodynamic concepts of antimicrobial therapy. This includes general concepts and insights into PK/PD modeling,  the use and application of  animal models and in vivo pharmacokinetics, protein binding, PK/PD indices and sub-MIC effects.  Ample time was allowed to help the adience to translate these concepts into clinical applications.
• Intended audience: physicians, clinical microbiologists, pharmacologists, pharmacists and anybody else interested and needing a basinc education in PK/PD.
• Level: basic to intermediate

Each participant has received a certificate for participation.

• ISAP Web site and ISAP on-line services generously housed and managed on the INTERNET Server of the Faculty of Medicine of the 'Université Catholique de Louvain' , Brussels, Belgium, with the expert help of Benoît Debande, MD.  All comments and queries should, however, be sent exclusively to the ISAP Webmaster .
• Leonardo da Vinci showing his projects ... Leonardo's ability to invent fantastic mechanical apparatuses and aquatic mechanisms for the court feasts together with his talent as a set designer, musician and inventor of emblems, mottoes, games and riddles made him extremely popular and well loved among the court. Between 1495 and 1498, in the refectory of Santa Maria delle Grazie in Milano, he painted the Last Supper , which became one of the most important works of the entire Renaissance. (This image has been taken from the Web page of the Rizzoli Corriere della Sera about a temporary exhibition " The Genius and his Passions (Leonardo da Vinci and the Last Supper A masterpiece and its precedents, innovations and reflection) held in Palazzo Reale in 2001; the original image is from the exhibition catalogue published by Skira-Artificio , Milan, Italy.
• other logos and pictures are from the WEB sites to which they are linked or are in the public domain.