Pharmacodynamics of Antimicrobials in Animal Models

William A. Craig, University of Wisconsin-Madison

7th ISAP Pharmacokinetics / Pharmacodynamics (PK / PD) Educational Workshop
San Diego, CA. September 26th, 2001

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Table of Contents

Pharmacodynamics of Antimicrobialsin Animal ModelsWilliam A. Craig, M.D.University of Wisconsin-Madison

Determination of “Static Dose” in Murine Thigh and Lung Infections

Relationship Between 6-Hour Dose and Number of Klebsiella pneumoniae in Thighs of Neutropenic Mice

Pharmacokinetic/PharmacodynamicParameters

PK/PD Parameters: ?-Lactams

Relationship Between MIC and T>MIC for Amoxicillin & Sanfetrinen with S. pneumoniae

Relationship Between T>MIC and Efficacy for Amoxicillin against Streptococcus pneumoniae in Rat Pneumonia and Murine Thigh-Infection Models

Relationship Between Time Above MIC and Efficacyin Animal Infection Models for S. pneumoniae

PK/PD Paramters with Fluoroquinolones

24-Hr AUC/MIC for Static Doses of Gatifloxacin, Sitafloxacin and Gemifloxacin Against 6 Strains of Streptococcus pneumoniae

Relationship Between 24 Hr AUC/MIC and Mortality forFluoroquinolones against Streptococcus pneumoniae in Immunocompetent Animals

Magnitude of PK/PD Parameter Required for Effective Dose-50 Against Candida albicans in Kidneys of Neutropenic Mice

Animal Models for Susceptibility Breakpoint Determinations

Growth of 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice

Effect of Amoxicillin (7 mg/kg) on 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice

Author: William A. Craig

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