In Vitro models of Infections: the postantibiotic and sub-MIC effects in vitro and in vivo

Inga Odenholt Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden

7th ISAP Pharmacokinetics / Pharmacodynamics (PK / PD) Educational Workshop
San Diego, CA. September 26th, 2001

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Table of Contents

In Vitro models of Infections:the postantibiotic and sub-MIC effects in vitro and in vivo

Pharmacodynamic parameters

Pharmacodynamic parameters

The postantibiotic effect in vitro

Postantibiotic effect; PAE in vitro

Postantibiotic effectin vitro

PAE against Gram-negative bacteria

PAE against P. aeruginosa

PAE in vitro Methods

PAE in vitro Methods

PAE in vitro Methods

PAE in vitro Methods

The postantibiotic effect in vivo

Postantibiotic effect in vivo

PAE in vivoAnimal models

Mechanisms of PAE

Mechanisms of PAE

Mechanisms of PAE

Postfungal effect

PAFE of Amphotericin B

PAFE on different conditions

PAFE for Itraconazole

The postantibiotic sub-MIC effect in vitro

Postantibiotic sub-MIC effect; PA SME

The postantibiotic sub-MIC effect in vivo

PAE ( PASME) in vivo of amikacin against K. pneumoniae in a thigh-infection model in mice

Post-MIC effect (PME)

Post-MIC effect; PME

Mechanism of PA SME?

Postantibiotic leucocyte enhancement

Postantibiotic leucocyte enhancement; PALE

Sub-MIC effects

Sub-MIC effects; SME

Sub-MIC effects

Sub-MIC effects

Mechanism of sub-MIC effects

Thank you very much for your attention

Author: Inga Odenholt

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