• Pre-meeting Introduction (goals and format)

The giant Panda in San Diego Zoo ...

Part 1: An Introduction to Pharmacokinetics and Pharmacodynamics The general concept of pharmacokinetics H. Derendorf, Department of Pharmaceutics, University of Florida, Gainsville, FL Antimicrobial pharmacokinetics: lessons learned from animal models W.A. Craig, Division of Infectious Diseases, University of Wisconsin, Madison, WI Protein binding, tissue concentrations : do they matter ?  O. Cars, Division of Infectious Diseases, University Hospital, Uppsala, Sweden Pharmacodynamic indices (peak / MIC, AUC / MIC, time > MIC, ...) J. Mouton, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Part 2: Advanced Issues in Pharmacodynamics:  PK/PD Modeling and Clinical Implications General concepts of PK/PD modelling: types of models Linear models, non-linear models, Emax models, kill curve fitting H. Derendorf, Department of Pharmaceutics, University of Florida, Gainsville, FL In-vitro models of infection: the post-antibiotic effect and sub-MIC effects Odenholt, Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden Pharmacodynamics of antimicrobials in animal models W.A. Craig, Division of Infectious Diseases, University of Wisconsin, Madison, WI Clinical Implications of PK/PD modelling J. Mouton, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs.  While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999, there is presently a lack of training into these disciplines.  Accordingly, ISAP has endeavoured to launch educational activities in this context.  The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown.

Since 1999, ISAP has organized 4 full-day educational workshops in association with ECCMID (1999, 2000, 2001) and ICAAC (2000) [see "Past Educational Activities"].  Following specific demands, and from the 5th educational workshop, the meeting wes organized as two successive parts (half a day each) dealing with the basic aspects of PK/PD and advanced studies, respectively. Each part was considered independent, but the two parts could also be combined.

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Useful links

	Home page of ISAP		The City of San Diego Official Web site The County of San Diego Official Web site San Diego Convention and Visitor Bureau The San Diego International Airport Web site "Golf Reservations in San Diego"  (a useful site with a lot of details and practical informations)
	42d Interscience Conference on Antimcrobial Agenst and Chemotherapy (ICAAC)		The San Diego Natural History Museum  The Museum of Contemporary Art in San Diego (and its sister site at La Jolla...) The San Diego Aerospace Museum The San Diego Railroad Museum (with rides...) The San Diego Zoo !
	San Diego Hotels and Resorts other hotels, ... and if you like golf !! a list of cheap accomodations !!! another list of Hotels ... and restaurants		Finding a resturant in San Diego California cook book... Rancho cooking (Mexican and Californian recipes)

Last update: December 26th,  2002

• The ISAP Web site and the ISAP on-line services are generously housed and managed on the INTERNET Server of the Faculty of Medicine of the 'Université Catholique de Louvain', Brussels, Belgium, with the expert help of Benoît Debande, MD.  All comments and queries should, however, be sent exclusively to the ISAP Webmaster.
• Giant Panda in San Diego... This very rare animal is to be seen (if you are lucky...) at the famous Zoo of Dan Siego...(photograph from the WEB site http://www.golfreservationsinsandiego.com,  a travel agency which specializes in Golf reservations and has a veryuseful WEB site on San Diego (see above)
• Other images are from the WEB sites to which they are linked.