Pharmacodynamics of Antifungals

10th ISAP Symposium
Pharmacokinetics and Pharmacodynamics (PK/PD) : towards definitive criteria

Milan, Italy -  April 27th-28, 2002

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Table of Contents

Pharmacodynamics of Antifungals

Value of Animal Models

Fungal Densities in Kidneys of Mice Treated with Various Fluconazole Total Doses Administered in 1, 2, or 4 Divided Doses

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Relationship Between 5-FC PK/PD and Efficacy

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Relationship Between Amphotericin B PK/PDP and Efficacy

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Relationship Between Fluconazole 24 h AUC/MIC and Outcome Against C. albicans with Varying MICs

Relationship Between Fluconazole Data Sets: AUC/MIC and Outcome Against C. albicans with Varying MICs

Fluconazole vs Murine Candidiasis in Literature

Fluconazole dose-response with 9 C. albicans strains with a ��-fold susceptibility

Correlation of Animal Fluconazole PK/PD to Clinical Trials and Susceptibility Breakpoints

Fluconazole/Candidemia Correlation

Fluconazole/Candidemia Correlation

PD for fluconazole and Candida

Comparative Efficacy of Ravuconazole Against 8 Strains of C. albicans

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Antifungal PK/PD Summary

Author: David Andes

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