PK/PD in clinical Practice: new level of PK/PD  ?

10th ISAP Symposium
Pharmacokinetics and Pharmacodynamics (PK/PD) : towards definitive criteria

Milan, Italy -  April 27th-28, 2002

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Table of Contents

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PK/PD results and evolution

Several objectives of PK/PD

PK/PD evolution

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Considerations when choosing an antibacterial agent

PK/PD parameters affecting efficacy

Improving the probability of positive outcomes

PK/PD parameters determining efficacy

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Peak level of tobramycin 3mg/kg in ten patients in ICU

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Ideal approach to adjust the dose

First problem PK approach to adjust the dose is poor applicable for routinely use (at moment)

second problem PK/PD breakpoints

Program to customize the therapy in our hospital

PK/PD values adopted

Sampling time

Concentrations of ceftazidime and cefotaxime in serum

Peak levels of amikacin

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preliminary results

diagnosis

Organisms isolated

outcome

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Conclusions I

Conclusions II

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Author: F. Scaglione

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