Antifungal drug efflux
Molecular mechanisms of azole resistance. Drugs enter the cell through an unknown mechanism (passive diffusion ?). Two types of efflux pumps are expressed at low levels.
In a "model" resistant cell, the drugs are less effective because … the azoles are effluxed through overexpression of the CDR (ABCT) and MDR (MF) genes. Adapted from White, T. C. 1997. Antifungal drug resistance in Candida albicans. ASM News 63:427-433