Pharmacodynamics of Antimicrobials in Animal Models

8th ISAP Educational Workshop, Glasgow, UK, May 10th, 2003

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Pharmacodynamics of Antimicrobialsin Animal ModelsWilliam A. Craig, M.D.University of Wisconsin-Madison

Effect of Increasing Concentrations on Killing of Pneumococci in Thighs of Neutropenic Mice

In Vivo PAE for Azithromycin with Streptococcus pneumoniae ATCC 10813 in Thighs of Neutropenic Mice

Correlation of PK/PD Parameters with Efficacy of Temafloxacin against Streptococcus pneumoniaein Thighs of Neutropenic Mice

Mathematical Analysis of Dose-Response Data from Animal Models after 24 Hours of Therapy

PK/PD Parameters: ?-Lactams

Relationship Between MIC and T>MIC for the Static Dose for Cefpodoxime and Cefditoren with Various Strains of S. pneumoniae

Literature Review for T>MIC for Beta-Lactams Versus Mortality in Animal Models

Relationship Between T>MIC and Bacterial Eradication with Beta-Lactams in Otitis Media (Circles) and Maxillary Sinusitis (Squares)

PK/PD Paramters with Fluoroquinolones

24-Hr AUC/MIC with Total and Free Drug for the Static Dose of Different Fluoroquinolones with S. pneumoniae ATCC 10813

Relationship Between 24 Hr AUC/MIC and Mortality in Animals for Fluoroquinolones against Gram-Negative Bacilli

Comparison of Relationships Between 24-Hr AUC/MIC and Efficacy against Pneumococci for Fluoroquinolones in Animals and Patients

Impact of Dosing Interval on Static Dose for Amikacin against K. Pneumoniae and E. coli in Mice with Normal and Impaired Renal Function

Impact of Dosing Frequency on Static Dose for Macrolides and Azalides with Streptococcus pneumoniae ATCC 10813

24-Hr AUC/MIC with Total and Free Drug for the Static Dose of Different Macrolides, Ketolides and Clindamycin with S. pneumoniae ATCC 10813

Animal Models for Susceptibility Breakpoint Determinations

Effect of Amoxicillin (7 mg/kg) on 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice

Author: W.A. Craig

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