Sub-MIC effects in vitro and in vivo

28th ISAP Educational Workshop, Glasgow, UK, May 10th, 2003

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Table of Contents

Sub-MIC effects in vitro and in vivo

PPT Slide

Pharmacodynamic indices

Pharmacodynamic indices

The postantibiotic effect in vitro

Postantibiotic effect; PAE in vitro

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Postantibiotic effect in vitro

PPT Slide

PAE against Gram-negative bacteria

PAE against P. aeruginosa

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PPT Slide

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PAE in vitro Methods

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PAE in vitro Methods

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PAE in vitro Methods

PPT Slide

The postantibiotic effect in vivo

Postantibiotic effect in vivo

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PAE in vivo

PAE in vivo

Mechanisms of PAE

Mechanisms of PAE

Mechanisms of PAE

Postfungal effect (PAFE)

PAFE assay

PAFE

PAFE of amphotericin B against Asperigillus fumigatus and ustus

PAFE for Itraconazole

The postantibiotic sub-MIC effect in vitro

Postantibiotic sub-MIC effect; PA SME

PPT Slide

PPT Slide

The postantibiotic sub-MIC effect in vivo

PAE ( PASME) in vivo of amikacin against K. pneumoniae in a thigh-infection model in mice

Post-MIC effect (PME)

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Post-MIC effect; PME

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Mechanism of PA SME?

Sub-MIC effects

Sub-MIC effects; SME

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Sub-MIC effects

Sub-MIC effects

Mechanism of sub-MIC effects

Implications

Thank you very much for your attention

Author: I. Odenholt

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Home Page: http://www.isap.org/slides.htm

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