Scientific organizers: Hartmut Derendorf, PhD (University of Florida, Gainesville, FL, USA) & Johan W. Mouton, MD (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)

Learning PK/PD the Scottish way ...

The general concept of pharmacokinetics and pharmacodynamics H. Derendorf (Department of Pharmaceutics, University of Florida, Gainesville, FL) Antimicrobial pharmacokinetics:  lessons learned from animal models W.A. Craig (Division of Infectious Diseases, University of Wisconsin, Madison, WI) Protein binding and tissue concentrations – do they matter ? U. Theuretzbacher (Antibiotic Center, University of Vienna, Vienna, Austria) PK/PD indices : definitions, how to determine and interpretation J. W. Mouton (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands) Animal models of infection W.A. Craig (Division of Infectious Diseases, University of Wisconsin, Madison, WI) Sub-MIC effects I. Odenholt  (Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden) Kill-curve analysis H. Derendorf (Department of Pharmaceutics, University of Florida, Gainesville, FL) Clinical Implications of PK/PD modelling Paul M. Tulkens (Cellular and Molecular Pharmacology, Catholic University of Louvain, Brussels, Belgium)

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs.  While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999, there is presently a lack of training into these disciplines.  Accordingly, ISAP has endeavoured to launch educational activities in this context.  The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown.  This 8th workshop of ISAP will continue the tradition of educational workshops initiated in Berlin, Germany, in 1999 and will inclide the latest developements discussed at ISAP research meetings and symposia during the last decade.

• Objectives: Participants will gain insight in pharmacokinetic and pharmacodynamic concepts of antimicrobial therapy. This includes the use and application of  animal models and in vitro pharmacokinetic models. Attention will be given to pharmacokinetic issues (protein binding, the value of tissue concentrations), pharmacodynamic issues (the use of pharmacodynamic parameters to describe and predict effect, Sub-MIC effects, post-antibiotic effects, differences between in vitro and in vivo) and the use of pharmacokinetic/pharmacodynamic modelling (the E-max model and other models). To illustrate theory, examples will be given how to use the above concepts in clinical practice and drug discovery.
• Intended audience: physicians, clinical microbiologists, pharmacologists, pharmacists and anybody else interested.
• Level: basic to intermediate

Each participant will receive a certificate for participation.

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