Vertical constellation from Calder ...

Part 1: Preclinical Pharmacokinetics and Pharmacodynamics of Anti-infective Agents 8:30 am - 12 noon Part 2: Clinical Relevance of Pharmacokinetics and Pharmacodynamics of Anti-infective Agents Part 3: PK/PD Modeling of Anti-infective Agents 1:00 pm-4:30 pm Goals and format Continuing education / Accreditation Venue | Accomodation | Registration Useful links | Credits

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs.  While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999), there is still a lack of training into these disciplines.  Accordingly, ISAP has endeavoured to launch educational activities in this context.  The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown.

Since 1999, ISAP has already organized several educational workshops in association with ECCMID and ICAAC [see "Past Educational Activities"].  Following specific demands, the educational workshop held with ICAAC since this year have been organized in three parts (half a day each) dealing with

1. preclinical aspects
2. analysis of the clinical relevance of PK/PD
3. PK/PD modeling

Objectives:

• Gain insight in pharmacokinetic and pharmacodynamic concepts of antimicrobial efficacy
• Application of in vitro models and animal models in pharmacodynamic research
• The limitations and use of serum and tissue concentrations
• Know how to calculate pharmacokinetic and pharmacodynamic parameters and interpret the results
• Drug resistance in vitro

Intended Audience: Medical microbiologists, infectious diseases specialists, pharmacologists, and others interested

Level: Beginning

Prerequisites: None

Preclinical Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
	Introduction to PK/PD	H. Derendorf, PhD Department of Pharmaceutics, University of Florida, Gainsville, FL
	PK/PD indices	J. Mouton, MD, PhD Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
	Protein binding, tissue distribution	U. Theuretzbacher Antibiotic Center, University of Vienna, Vienna, Austria
	In vitro models	I. Odenholt, MD Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden
	Animal models	W.A. Craig, Division of Infectious Diseases, University of Wisconsin, Madison, WI
	In vitro resistance	O. Cars, Division of Infectious Diseases, University Hospital, Uppsala, Sweden

• Gain insight in the clinical significance of pharmacokinetic and pharmacodynamic modeling of antimicrobials
• Application of preclinical PK/PD into clinical drug development
• PK/PD of antivirals and antifungals
• Assessment of drug exposure at the site of infection
• Clinical drug resistance

Clinical Relevance of Pharmacokinetics and Pharmacodynamics of Anti-infective Agents
	Clinical applications of PK/PD	Paul M. Tulkens, MD,PhD Department of Pharmaceutics, Catholic University of Louvain, Brussels, Belgium
	Drug exposure at infection site	M. Mueller, MD Department of Clinical Pharmacology, Vienna University Medical School, Vienna, Austria.
	PK/PD of antivirals	G.L. Drusano, MD Division of Clinical Pharmacology, Albany Medical College, Alabany, NY
	PK/PD of antifungals	D.R. Andes, MD Department of Medicine, University of Wisconsin Medical School, Madison, WI
	Clinical resistance	O. Cars, MD, MPH Division of Infectious Diseases, University Hospital, Uppsala, Sweden
	Clinical dose optimization	J. Mouton, MD, PhD Canisius Wilhelmina Hospital, Nijmegen, The Netherland

• MIC based PK/PD modeling in vitro and in animals
• PK/PD based on kill curves
• Population PK/PD of anti-infective agents
• Monte Carlo Simulations
• Integration of preclinical and clinical PK/PD

PK/PD Modeling of Anti-infective Agents
	In vitro MIC based PK/PD	A.P. MacGowan, MD,PhD Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust & University of Bristol Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK
	PK/PD in animals	W.A. Craig, Division of Infectious Diseases, University of Wisconsin, Madison, WI
	PK/PD based on kill curves	H. Derendorf, PhD Department of Pharmaceutics, University of Florida, Gainsville, FL
	Population PK/PD	A.A. Vinks, PhD Division of Pharmacology Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
	Modeling of anti-infective activity	A. Forrest, PhD Clinical Pharmacokinetics Laboratory (CPL), Uiversity of New York at Buffalo, Buffalo, NY
	Monte Carlo Simulations	G.L. Drusano, MD Division of Clinical Pharmacology, Albany Medical College, Alabany, NY

This will be handled by the American Society for Microbiology (ASM).  ASM is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.  ASM has designated full-day workshops for 7 hours of category 1 credit towards the American Medical Association Physician's Recognition Award. Diplomates of the American Board of Medical Microbiology, Diplomates of the American Board of Medical Laboratory Immunology, and Registrants of the National Registry of Microbiologists may earn category 1 credit toward recertification. Each physician should claim only those hours of credit that he/she actually spent in the educational activity.

The workshop will take place in Washington, DC, at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).  Room no. will be posted clearly at the entrance of the Convention Center.  Please, refer to the ICAAC Web site (http://www.icaac.org) site for all additional and "up to the last minute" details.

ISAP will not be responsible for accomodation which must be taken care of individually by each participant.  Attendants participating to the  may wish to take advantage of the offerings made by the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Please, refer to the ICAAC Web site (http://www.icaac.org) site for all additional and "up to the last minute" details. See also the "Useful links" section hereunder.

Registration is open to all ISAP members and to all professionals active or having interest in the pharmacokinetics and pharmacodynamics of antiinfective agents. 
Registration is exclusively through the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).  Please, refer to the ICAAC Web site (http://www.icaac.org) site for registration. 

Important: As per ICAAC policy, attendance to workshops is limited (so as to foster interactivity and real discussions).  Registration to workshops is made by ICAAC on a first-come first-served basis.  Our experience is that these PK/PD workshops fill up pretty quickly, so that early registration is recommended.  Please, do not contact ISAP in this context. 

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Useful links

	Home page of ISAP		Practical and useful information on Washington and the District of Columbia Visitor resource Center DC guide on-line Exploring DC ... Historic neighborhoods... History of Washington DC
	44d Interscience Conference on Antimicrobial Agenst and Chemotherapy (ICAAC)		Accomodation and restaurants Hotels and accomodation (through the Visitor Resource Center...) Bed & Breakfast (through bb-on-line...) Guide of restaurants (through the Washinghtonian...)

Last update: February 7th, 2004

• The ISAP Web site and the ISAP on-line services are generously housed and managed on the INTERNET Server of the Faculty of Medicine of the 'Université Catholique de Louvain', Brussels, Belgium, with the expert help of Benoît Debande, MD.  All comments and queries should, however, be sent exclusively to the ISAP Webmaster.
• Alexander Calder: Vertical Constellation with Bomb, 1943, painted steel wire, painted wood, and wood, National Gallery of Art, Washington, Gift of Mr. and Mrs. Klaus G. Perls 1996. This beautiful and aerial  construction, somewhat reminiscent of our multiples curves, peaks, troughts and other AUCs... is on display close from where the workshop will take place.  The whole Gallery is a must to visit ! 
  
• Other images are from the WEB sites to which they are linked.