15th ISAP International Symposium
Surrogate Markers in the development of Anti-infectives

A post-ICAAC 2005 meeting, Washington, DC (Monday December 19th, 2005 - 1:00 - 6:00 pm)

co-organizers: Jerome J Schentag, Pharm.D., FCP (Buffalo, NY) & Hartmut Derendorf, Ph.D. (Gainesville, FL)

Note: The slides presented by the some of the speakers at this workshop are available on this site as "Web slide shows" and as ".PDF files". To view and/or to download them, click on the title of the lectures. These slides, which reflect the views of their authors and should not be taken as being endorsed by ISAP, are for information purposes only. They cannot be reproduced or used for any form of presentations without the autorization of their author and of ISAP. Please, contact the ISAP Webmaster for further information.



Bayous in Louisiana...

This picture was selected to illustrate our programme as a nice symbol of the New Orleans beauatiful surroundings. While it may now suggest more miseries than beauties, we want to keep it here as a mark of sympathy to Louisiana population, with the hope that Bayous will be soon again a real place of beauty

Short presentations by young scientists

  • P.A. Moise-Broder, A. Forrest, J.J. Schentag (Buffalo, NY)
    Relationship between time to eradication in vivo and bactericidal activity in vitro of vancomycin for MRSA infections WEB show - PDF
  • S. Lemaire, F. Van Bambeke, M.-P. Mingeot-Leclerq, Y. Glupczynski, P.M. Tulkens (Brussels, Belgium)
    Activity of carbapenems against intracellular MRSA - WEB show - PDF
  • J. Zack, A. Forrest, S. Bilic, P. Kelchlin, P.F. Smith (Buffalo, NY)
    PK/PD in silico & in vitro simulations of linezolid (LZD) activity against methicillin resistant Staphylococcus aureus (MRSA) - Web show - PDF
  • J. Bulitta, S.B. Dufull, M. Kinzig-Schippers, U. Holzgrabe, U. Stephan, F. Sörgel (Nürnberg, Germany)
    Cystic fibrosis patients are pharmacokinetically comparable to healthy volunteers - Web show - PDF
  • Y.F. Brun, B.H. Segal, C.G. Dennis, R. Youn, D.B. White, W.R. Greco (Buffalo, NY)
    Modeling of the three antifungal agent combination (amphotericin B + micafungin + nikkomycin Z) against Aspergillus fumigatus in vitro using a novel response surface paradigm - WEB show - PDF
  • O.O. Okusanya, A. Forrest, P.F. Smith (Buffalo, NY)
    A novel PK/PD model for cefprozil (CPZ) vs. Hemophilus influenzae (HI) in an in vitro infection model (IVM) - Web show - PDF)

Full presentations

  • George Talbot, MD (Talbot Advisors, Wayne, Md)
    The dwindling Pipeline of Anti-infectives, a Medical Need and a cry for Innovation in Study Design
    Web show - PDF

  • Alan Forrest, Pharm.D. (School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY)
    Patient studies modeling Surrogates and their Linkages: MICs, Clinical Scoring, and PK/PD indices of effect
    Web show - PDF

  • George Drusano, M.D. (Ordway Research Institute, Albany, NY)
    Convincing the Pharmaceutical Industry to use Surrogates for Antibiotic Development: What is gained, and What is Lost
    Web show - PDF

  • John Powers, M.D. (US Food & Drug Adminstration, Rockville, Md)
    Role of Surrogate Markers in the development of Antibiotics, FDA Perspective
    Web show - PDF

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Credits:
last significant update: December 30, 2005