Workshops of ISAP

13th ISAP Pharmacokinetics / Pharmacodynamics (PK / PD) Educational Workshop
Washinghton, DC, December 15th, 2005
An official workshop ot the 45d Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Scientific organizers: Johan W. Mouton, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands & H. Derendorf, University of Florida, Gainesville, Fla.
(this is the rescheduling of the workshop that should have taken place in New Orleans, LA on September 20th)

New Orleans in 1920 :
View of Canal street ...

This image was chosen and posted when we thought that New Orleans would once again house ICAAC and ISAP. Canal street has been flooded like most of the rest of New Orleans aftre hurricane Katrina at the end of August. We will keep this picture in our programme of the workshop as a mark of sympathy for all our colleagues and inhabitants of New Orleans with all our encouragements for a fast and safe reconstruction.

Part 1: Preclinical Pharmacokinetics and Pharmacodynamics of Anti-infective Agents

Introduction to PK/PD (H. Derendorf; Department of Pharmaceutics, University of Florida, Gainsville, FL)
PK/PD indices (J. Mouton; Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)
Protein binding, tissue distribution (U. Theuretzbacher; Center for Anti-Infective Agents, Vienna, Austria).
In vitro models (I. Odenholt; Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden)
Animal models (W.A. Craig; Division of Infectious Diseases, University of Wisconsin, Madison, WI)
In vitro resistance (O. Cars; Division of Infectious Diseases, University Hospital, Uppsala, Sweden)

Part 2: Clinical Relevance of Pharmacokinetics and Pharmacodynamics of Anti-infective Agents

Clinical applications of PK/PD (Paul M. Tulkens: Department of Pharmaceutics, Catholic University of Louvain, Brussels, Belgium)
Drug exposure at infection site (M. Mueller; Department of Clinical Pharmacology, Vienna University Medical School, Vienna, Austria).
PK/PD of antivirals (G.L. Drusano; Division of Clinical Pharmacology, Albany Medical College, Alabany, NY)
PK/PD of antifungals (D.R. Andes; Department of Medicine, University of Wisconsin Medical School, Madison, WI)
Clinical resistance (O. Cars, Division of Infectious Diseases, University Hospital, Uppsala, Sweden)
Clinical dose optimization (J. Mouton; Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)

Part 3: PK/PD Modeling of Anti-infective Agents

In vitro MIC based PK/PD (A.P. MacGowan; Bristol Centre for Antimicrobial Research and Evaluation, North Bristol NHS Trust & University of Bristol Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol, UK)
PK/PD in animals (W.A. Craig; Division of Infectious Diseases, University of Wisconsin, Madison, WI)
PK/PD based on kill curves (H. Derendorf; Department of Pharmaceutics, University of Florida, Gainsville, FL)
Population PK/PD (A.A. Vinks; Division of Pharmacology Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH)
Modeling of anti-infective activity (A. Forrest; Clinical Pharmacokinetics Laboratory (CPL), Uiversity of New York at Buffalo, Buffalo, NY)
Monte Carlo Simulations (G.L. Drusano; Division of Clinical Pharmacology, Albany Medical College, Alabany, NY)

Goals and format
Continuing education / Accreditation
Useful links | Credits

Goals and Format

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999), there is still a lack of training into these disciplines. Accordingly, ISAP has endeavoured to launch educational activities in this context. The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown.

Since 1999, ISAP has already organized several educational workshops in association with ECCMID and ICAAC [see "Past Educational Activities"]. Following specific demands, the educational workshop held with ICAAC since this year have been organized in three parts (half a day each) dealing with

preclinical aspects
analysis of the clinical relevance of PK/PD
PK/PD modeling

Each part can be followed independently, but parts 1 and 2, or 1 and 3 can also be combined.

Continuing Education / Acreditation

This will be handled by the American Society for Microbiology (ASM). ASM is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians. ASM has designated full-day workshops for 7 hours of category 1 credit towards the American Medical Association Physician's Recognition Award. Diplomates of the American Board of Medical Microbiology, Diplomates of the American Board of Medical Laboratory Immunology, and Registrants of the National Registry of Microbiologists may earn category 1 credit toward recertification. Each physician should claim only those hours of credit that he/she actually spent in the educational activity.

Useful links

Home page of ISAP

45th Interscience Conference on Antimicrobial Agenst and Chemotherapy (ICAAC)

Last update: September 3d, 2004

Back to ISAP home page

Credits

The ISAP Web site and the ISAP on-line services are generously housed and managed on the INTERNET Server of the Faculty of Medicine of the 'Université Catholique de Louvain', Brussels, Belgium, with the expert help of Benoît Debande, MD. All comments and queries should, however, be sent exclusively to the ISAP Webmaster.
Canal street in 1920... In the 1920s an effort to "modernize" the look of the city of New Orleans removed the old cast-iron balconies from Canal Street, the city's commercial hub. In the 1960s another "modernization" effort replaced the Canal Streetcar Line with busses. Both of these moves came to be regarded as mistakes long after the fact, and the streetcars returned to a portion of Canal Street at the end of the 1990s, and construction to restore the entire line is underway. Taken from the WEB site of Kowledgerush 41722 Putters Green Court Leesburg, VA 20176 (http://www.knowledgerush.com/kr/jsp/db/facts.jsp?title=New+Orleans). This article is licensed under the GNU Free Documentation License.
Other images are from the WEB sites to which they are linked.

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