14th ISAP Educational Workshop
Pharmacokinetics and Pharmacodynamics of
Anti-Infective Agents
Nice, France,
April 1, 2006; 13:30-17:30
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- Introduction
to PK/PD
H.
Derendorf (Department of Pharmaceutics,
University of Florida, Gainesville, FL)
- PK/PD indices
J.
W. Mouton (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)
- Protein
Binding/Tissue Distribution
U. Theuretzbacher
(Center for Anti-Infective Agents, Vienna, Austria)
- In vitro models
I. Odenholt
(Departement of Infectious Diseases, Malmö University Hospital,
Malmö, Sweden)
- Animal
models of infection
W.A. Craig (Division
of Infectious Diseases, University of Wisconsin, Madison, WI)
- PK/PD and resistance
O. Cars (Division
of Infectious Diseases, University Hospital, Uppsala, Sweden)
- Clinical
Implications of PK/PD modeling
Paul M.
Tulkens (Cellular and Molecular Pharmacology & Centre for
Clinical Pharmacy, Catholic University of Louvain, Brussels, Belgium)
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Goals and Format
Pharmacokinetics
and Pharmacodynamics (PK/PD) have now become essential tools for determining
the appropriate use of currently available anti-infective agents as well as
for accelerating the development of new drugs. While this is now more
and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP
/ FDA and ISAP / EMEA workshops held
in 1999, there is presently a lack of training into these disciplines.
Accordingly, ISAP has endeavoured to launch educational activities in
this context. The aim is to train people professionally involved in development
or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics
and pharmacodynamics, showing how these sciences have emerged over the last
10 years and how their influence has grown. This 14th workshop of ISAP will continue the tradition
of European Educational Workshops initiated in 1999 at the occasion of
the 9th
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
(Berlin, Germany; see http://www.isap.org/Berlin-1999.htm).
This type of worshop has thereafter been organized at every subsequent ECCMID
meeting (Stockholm, Sweden, 2000;
Istanbul, Turkey, 2001;
Milan, Italy, 2002;
Glasgow, Scotland,
2003; Prague, Czech Republic, 2004;
and Copenhagen, Denmark, 2005)
- Objectives: Participants
will gain insight in pharmacokinetic and pharmacodynamic concepts of antimicrobial
therapy. This includes the use and application of animal models and
in vitro pharmacokinetic models. Attention will be given to pharmacokinetic
issues (protein binding, the value of tissue concentrations), pharmacodynamic
issues (the use of pharmacodynamic parameters to describe and predict effect,
Sub-MIC effects, post-antibiotic effects, differences between in vitro and
in vivo) and the use of pharmacokinetic/pharmacodynamic modelling (the E-max
model and other models). To illustrate theory, examples will be given how
to use the above concepts in clinical practice and drug discovery.
- Intended audience:
physicians, clinical microbiologists, pharmacologists, pharmacists and anybody
else interested.
- Level: basic to intermediate
The workshop will be
informal and each part will consist of a 15-20 minutes talk followed by
a
10 minutes "Questions & Answers" period. Every participant
will be encouraged to ask questions (there are no stupid questions !!).
Each participant will
receive
- copies of all
slides of all presentations (hand-outs) at the meeting and a link to a Web
site for download of a full PDF version of all lectures (available
about 10 days after the meeting) ;
- a certificate
for participation.
Back
to ISAP home page
Credits
- ISAP Web site and ISAP on-line
services generously housed and managed on the INTERNET Server of the Faculty
of Medicine of the 'Université Catholique de Louvain', Brussels,
Belgium, with the expert help of Benoît Debande, MD. All comments
and queries should, however, be sent exclusively to the ISAP
Webmaster.
- Nice, sun and flowers: a poster from the well
knwon Russian-French artist Chagall who spent a long part of his life in Nice.
Nice, famous for its blend of sun and flowers has attracted many artists.
You should not miss visiting the Chagall Museum (http://www.musee-chagall.fr)
before or after or workshop...
- other logos and pictures are
from the WEB sites to which they are linked or are in the public domain.
