Workshops of ISAP

18th ISAP Educational Workshop
Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents
Barcelona, Spain, April 2008

In cooperation with the 18th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
Scientific organizers: Johan W. Mouton, MD (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)
Goals and Format
Credits

Modern Barcelona ...

Introduction to PK/PD
H. Derendorf (Department of Pharmaceutics, University of Florida, Gainesville, FL)
PK/PD indices
J. W. Mouton (Canisius Wilhelmina Hospital, Nijmegen, The Netherlands)
Protein Binding/Tissue Distribution
U. Theuretzbacher (Center for Anti-Infective Agents, Vienna, Austria)
Use of in vitro models to study emergence of resistance
I. Odenholt (Departement of Infectious Diseases, Malmö University Hospital, Malmö, Sweden)
From animal models to the patient
W.A. Craig (Division of Infectious Diseases, University of Wisconsin, Madison, WI)

Hand-out of all presentations (3 slides per page with space for notes)

Goals and Format

Pharmacokinetics and Pharmacodynamics (PK/PD) have now become essential tools for determining the appropriate use of currently available anti-infective agents as well as for accelerating the development of new drugs. While this is now more and more recognized by Academia, Industry and Regulatory Agencies (see the ISAP / FDA and ISAP / EMEA workshops held in 1999, there is presently a lack of training into these disciplines. Accordingly, ISAP has endeavoured to launch educational activities in this context. The aim is to train people professionally involved in development or in the use of antiinfective drugs in the basic and applied aspects of pharmacokinetics and pharmacodynamics, showing how these sciences have emerged over the last 10 years and how their influence has grown. This 14th workshop of ISAP will continue the tradition of European Educational Workshops initiated in 1999 at the occasion of the 9th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) (Berlin, Germany). This type of worshop has thereafter been organized at every subsequent ECCMID meeting.

Objectives: Participants gain insight in pharmacokinetic and pharmacodynamic concepts of antimicrobial therapy. This includes the use and application of animal models and in vitro pharmacokinetic models. Attention will be given to pharmacokinetic issues (protein binding, the value of tissue concentrations), pharmacodynamic issues (the use of pharmacodynamic parameters to describe and predict effect, Sub-MIC effects, post-antibiotic effects, differences between in vitro and in vivo) and the use of pharmacokinetic/pharmacodynamic modelling (the E-max model and other models). To illustrate theory, examples will be given how to use the above concepts in clinical practice and drug discovery.
Intended audience: physicians, clinical microbiologists, pharmacologists, pharmacists and anybody else interested.
Level: basic to intermediate

The workshop are informal and each part will consist of a 15-20 minutes talk followed by a 10 minutes "Questions & Answers" period. Every participant will be encouraged to ask questions (there are no stupid questions !!).

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Credits

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Modern Barcelona: this photograph shows the new building "Torre Agbar" built in Barcelona by the French Architect Jean Nouvel. While Barcelona may be better known from the architecture of Gaudi, there are many architects who contributed in the past, and continue to contribute today, to the exceptional landscape of this city. The "Torre Agbar" is only one of the many examples that can be seen while strolling through the streets of Barcelona.
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