Pharmacodynamics: Issues of Concern
Current Shortcomings of Pharmacodynamic Analysis
Proper dosing has a Dual Effect
Proper dosing has a Dual Effect (cont.)
Mechanisms of Bacterial Killing By Antibiotics
Pharmacodynamic Relationship: AUC/MIC
Pharmacodynamics
Bacterial Killing as a Function of MIC
Important Clinical Resistance Phenomena
To Maximize Bacterial eradication and to Suppress the Emergence of Resistance
Pharmacodynamic Parameters
What is the Correct AUC/MIC?
Clinical Efficacy is Multivariate
Issues Associated with Resistance Reporting
General Relationship Between MIC’s and Clinical Cures (Claforan)
PPT Slide
Pharmacodynamic Parameters as a Guide to Decision Making
Pharmacodynamic Parameter
Oral Quinolone Pharmacodynamics: S. pneumoniae (Pharmacodynamic Order)
Dose Response Curve: Quinolones versus S. pneumoniae
Important Property of Macrolides
Pharmacodynamics of Macrolides/Azilides against H. influenzae
Differentiation between Pathogens and Colonizers
Bacterial Location/Infection
Time Dependent Pharmacodynamic Model
Macrolide Pharmacodynamic Model
Email: webmaster@isap.org
Home Page: http://www.isap.org/Berlin-1999.htm