Integration of Pharmacokinetics and Pharmacodynamics for Drug X
MIC90 for Drug X against penicillin-resistant S. pneumoniae and Enterobacteriacea is 1.0 and 0.5 mg/L, respectively
An oral dose of 500 mg produces mean serum levels that exceed a MIC of 1.0 mg/L for 3 hrs (37.5% and 25% of 8 and 12 hr dosing intervals, respectively) and a MIC of 0.5 for 4 hrs (50% and 33% of 8 and 12 hr dosing intervals, respectively)