Prediction of Antimicrobial Therapy Outcome: A Tree-Based Modeling Approach

25/03/99


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Table of Contents

Prediction of Antimicrobial Therapy Outcome: A Tree-Based Modeling Approach

Objectives…..

Outline

Proposed PD Variables

Cmax/MIC; AUC/MIC Determination

Proposed PD Variables…contd.

Time Above MIC Determination

Time Above MIC Determination

Proposed PD Variables….contd.

What Drives the PD Variables?

What Can We Deduce From These?

Modeling Approaches

Modeling Approaches….contd

Modeling Approaches…contd

Tree-Based Modeling (TBM)

Tree-Based Modeling (TBM)

Illustration of PK/PD Analyses

Simulated Data

Estimated PD Variables

The Question

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Clinical Trial Data

Estimated PD Variables

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The Question

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Conclusions from Analyses

Applications of Tree-Based Modeling Approach: Clinical Pharmacology

MIC Breakpoint Determination: Current Method

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The Question

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Applications of Tree-Based Modeling Approach: Microbiology

Overall Summary

Acknowledgment

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Author: Funmi Ajayi

Home Page: http://www.isap.org/past_activities.htm#ISAP/FDA workshop