Animal Models: Use in the Evaluation of Anti-Infective Agents William A. Craig, M.D. University of Wisconsin-Madison
Animal Versus In-Vitro Models
PPT Slide
Serum Versus Tissue Concentrations
24-Hr AUC/MIC Required for 1 Log Kill of E.coli in Thighs of Neutropenic Mice
Relationship Between 6-Hour Dose and Number of Klebsiella pneumoniae in Thighs of Neutropenic Mice
Pharmacokinetic/Pharmacodynamic Parameters
Relationship Between Time Above MIC and Efficacy in Animal Infection Models for S. pneumoniae
Time Above MIC vs Efficacy in Acute Otitis Media and Acute Sinusitis
Relationship Between 24-Hr AUC/MIC and Efficacy of Ciprofloxacin in 64 Patients with Serious Bacterial Infections
Time above MIC Required for Efficacy of Drug X in Animal Infection Models
Integration of Pharmacokinetics and Pharmacodynamics for Drug X
Dose Determining Studies for Drug X
24-Hr AUC/MIC Required for Efficacy of Drug Y in Animal Infection Models
Percent Reaching Target AUC/MIC for Static Dose by MIC and Species Following Standard Dose
Percent Expected to Reach Target AUC/MIC When Integrated Over MIC Distribution
Animal Models for Susceptibility Breakpoint Determinations
Growth of 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice
Effect of Amoxicillin (7 mg/kg) on 17 Strains of S. pneumoniae in Thighs of Neutropenic Mice
Conclusions
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