Defining the Requirements for an Intracellular Antibiotic
PPT Slide
Pathobiology question: Where are the bacteria ?
Here they are ...
1st PK answer : accumulation in cells
2d PK answer: subcellular localization
3d PK answer: Moving through cell
4th PK answer : efflux ?
1st PD answer: expression of activity
2d PD answer: bacterial responsiveness
3d PD answer: cooperation host defenses ? (a) cell bactericidal mechanisms
3d PD answer: cooperation host defenses ? (b) cytokines
3d PD answer: cooperation host defenses ? an example with Listeria monocytogenes
Which are the parameters to look for ?
Can we define breakpoints for intracellular bacteria ?
Thanks to ...
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