Continuous Infusion of Antibiotics in the Clinic
Early Controversy
PK/PD Analysis of Schmidt Data
“Continuous” vs “Discontinuous” Penicillin
Outpatient Parenteral Antimicrobial Therapy (OPAT)
PK/PD Implications for Optimal Dosing Regimens
Enhancement of Time > MIC
Continuous vs Intermittent Infusion
CI vs II of ?-lactams in Animals
CI of ?-lactams in Humans
Cephamandole CI vs II + Carbenicillin in Febrile Malignancy - Subgroup Analysis
Ceftazidime CI in Neutropenia
Ceftazidime CI vs II in Sepsis
Ceftazidime CI in Cystic Fibrosis
Flucloxacilin CI after II in MSSA Sepsis
Reasons to Change II to CI
Cefuroxime CI vs II
Ceftazidime CI vs II
Oxacillin CI vs II
Vancomycin CI in Humans
CI vs II of Aminoglycosides in Humans
CI of ?-lactams at University Hospitals
Organisms Treated with CI ?-lactams
Case Study - Viridans strep IE
Therapeutic Drug Monitoring in CI of ?-lactams
Loading Dose Requirements for CI
Serum Concentrations of CI
Continuous Infusion in the Clinic
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