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Some selected major PK/PD publications

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus: RL Nation, J Li, O. Cars, W. Couet, MN Dudley, KS Kaye, JW Mouton, DL Paterson, VH Tam, U. Theuretzbacher, BT Tsuji, JD Turnidge.
The Lancet Infectious Diseases, Early Online Publication, 21 October 2014
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Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

Jason A Roberts, Mohd H Abdul-Aziz, Jeff rey Lipman, Johan W Mouton, Alexander A Vinks, Timothy W Felton, William W Hope, Andras Farkas, Michael N Neely, Jerome J Schentag, George Drusano, Otto R Frey, Ursula Theuretzbacher, Joseph L Kuti, on behalf of The International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases

Lancet Infect Dis April 2014
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Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.

Gonzalez D, Schmidt S, Derendorf H.
Clin Microbiol Rev. 2013 Apr;26(2):274-88.

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New EMA guideline for antimicrobial development.

Ambrose PG, Bhavnani SM, Dudley MN, Ellis-Grosse E, Rubino CM, Drusano GL.
Lancet Infect Dis. 2012 Apr;12(4):265-6.

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Saving Lives with Optimal Antimicrobial Chemotherapy.

Drusano GL, Lodise TP
Clin Infect Dis 2012 Oct 16

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Predicting bacterial fitness cost associated with drug resistance.

Guo B, Abdelraouf K, Ledesma KR, Nikolaou M, Tam VH.
J Antimicrob Chemother. 2012 Apr;67(4):928-32.

Fundamentals of Population Pharmacokinetic Modelling: Modelling and Software.

Kiang TK, Sherwin CM, Spigarelli MG, Ensom MH.
Clin Pharmacokinet. 2012 Aug 1;51(8):515-25.

The role of pharmacokinetics/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach.

Mouton JW, Brown DF, Apfalter P, Cantón R, Giske CG, Ivanova M, MacGowan AP, Rodloff A, Soussy CJ, Steinbakk M, Kahlmeter G.
Clin Microbiol Infect. 2012 Mar;18(3):E37-45

Colistin pharmacokinetics: the fog is lifting.

Couet W, Grégoire N, Marchand S, Mimoz O.
Clin Microbiol Infect. 2012 Jan;18(1):30-9.

Conserving antibiotics for the future: new ways to use old and new drugs from a pharmacokinetic and pharmacodynamic perspective.

Mouton JW, Ambrose PG, Canton R, Drusano GL, Harbarth S, MacGowan A, Theuretzbacher U, Turnidge J.
Drug Resist Updat. 2011 Apr;14(2):107-17

The effect of critical illness on drug distribution.

Gonzalez D, Conrado DJ, Theuretzbacher U, Derendorf H.
Curr Pharm Biotechnol. 2011 Dec;12(12):2030-6.

Protein binding: do we ever learn?

Zeitlinger MA, Derendorf H, Mouton JW, Cars O, Craig WA, Andes D, Theuretzbacher U.
Antimicrob Agents Chemother. 2011 Jul;55(7):3067-74.

Pharmacokinetic/pharmacodynamic (PK/PD) indices of antibiotics predicted by a semimechanistic PKPD model: a step toward model-based dose optimization.

Nielsen EI, Cars O, Friberg LE.
Antimicrob Agents Chemother. 2011 Oct;55(10):4619-30

In vitro pharmacodynamic models to determine the effect of antibacterial drugs.

Gloede J, Scheerans C, Derendorf H, Kloft C.
J Antimicrob Chemother. 2010 Feb;65(2):186-201.

Significance of protein binding in pharmacokinetics and pharmacodynamics.

Schmidt S, Gonzalez D, Derendorf H.
J Pharm Sci. 2010 Mar;99(3):1107-22.

A long journey from minimum inhibitory concentration testing to clinically predictive breakpoints: deterministic and probabilistic approaches in deriving breakpoints.

Dalhoff A, Ambrose PG, Mouton JW.
Infection. 2009 Aug;37(4):296-305.

Back to the future: using aminoglycosides again and how to dose them optimally.

Drusano GL, Ambrose PG, Bhavnani SM, Bertino JS, Nafziger AN, Louie A.
Clin Infect Dis. 2007 Sep 15;45(6):753-60


Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it's not just for mice anymore.

Ambrose PG, Bhavnani SM, Rubino CM, Louie A, Gumbo T, Forrest A, Drusano GL.
Clin Infect Dis. 2007 Jan 1;44(1):79-86.

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
Johan W. Mouton, Michael N. Dudley, Otto Cars, Hartmut Derendorf and George L. Drusano
Journal of Antimcrobial Chemotherapy (2005) 55: 601-607